McCain reiterates his support for "comprehensive immigration reform" and pledges to make this reform a top priority of a potential first term:

After several of the business leaders complained about the difficulty in obtaining temporary H1B visas for scientists and engineers, something the Senate immigration bill was supposed to address, Mr. McCain expressed regret the measure did not pass, calling it a personal “failure,” as well as one by the federal government.

“Senator Kennedy and I tried very hard to get immigration reform, a comprehensive plan, through the Congress of the United States,” he said. “It is a federal responsibility and because of our failure as a federal obligation, we’re seeing all these various conflicts and problems throughout our nation as different towns, cities, counties, whatever they are, implement different policies and different programs which makes things even worse and even more confusing.”

He added: “I believe we have to secure our borders, and I think most Americans agree with that, because it’s a matter of national security. But we must enact comprehensive immigration reform. We must make it a top agenda item if we don’t do it before, and we probably won’t, a little straight talk, as of January 2009.”

So McCain emphasizes his opposition to local measures in order to deal with "illegal immigration" and, seemingly, piecemeal federal measures.
(H/T: Hot Air)